Add mouse cells

embryo-frontend/src/pages/EmbryoGeneration.tsx

@@ -1,40 +1,167 @@
-import React, { useState, useEffect, useRef } from "react";
+import React, { useState, useEffect, useRef, useCallback } from "react";
 import axios from "axios";
 import * as THREE from "three";
 import { OrbitControls } from "three/examples/jsm/controls/OrbitControls.js";
 import "../style.css";
-
 interface Point {
   x: number;
   y: number;
   z: number;
   value: number | string;
 }
+interface CameraParameters {
+  fov: number;
+  near: number;
+  far: number;
+  position: THREE.Vector3;
+  lookAt: THREE.Vector3;
+}
+interface LayoutConfig {
+  leftOffsetX: number;
+  rightOffsetX: number;
+  targetOffsetX?: number;
+  cameraParams: CameraParameters;
+  transFunc?: (a: Point) => Point;
+}
+interface AnimationSectionConfig {
+  id: string;
+  title: string;
+  description: string;
+  stages: {
+    sourceLeft: string;
+    sourceRight: string;
+    target: string;
+  };
+  layout: LayoutConfig;
+}
+const ANIMATION_SECTIONS: AnimationSectionConfig[] = [
+  {
+    id: "human-cs",
+    title: "Human Carnegie stages",
+    description: "CS7 and CS8 point clouds converge into CS7.5 to highlight human embryonic development.",
+    stages: {
+      sourceLeft: "CS7",
+      sourceRight: "CS8",
+      target: "CS7.5"
+    },
+    layout: {
+      leftOffsetX: -0.5,
+      rightOffsetX: 0.5,
+      targetOffsetX: 0,
+      cameraParams: {
+        fov: 30,
+        near: 0.1,
+        far: 1000,
+        position: new THREE.Vector3(0, 0, 30),
+        lookAt: new THREE.Vector3(0, 0, 0)
+      }
+    }
+  },
+  {
+    id: "mouse-early",
+    title: "Mouse early gastrulation",
+    description: "Mouse 7.5 and 7.75 datasets merge toward stage 8.5, mirroring the human pipeline.",
+    stages: {
+      // sourceLeft: "GSM9046243_Embryo_E7.5_stereo_rep1",
+      // sourceRight: "GSM9046247_Embryo_E8.0_stereo_rep1",
+      // target: "GSM9046245_Embryo_E7.75_stereo_rep1"
+      sourceLeft: "GSM9046244_Embryo_E7.5_stereo_rep2",
+      sourceRight: "GSM9046248_Embryo_E8.0_stereo_rep2",
+      target: "GSM9046246_Embryo_E7.75_stereo_rep2"
 
+    },
+    layout: {
+      leftOffsetX: -0.3,
+      rightOffsetX: 0.3,
+      targetOffsetX: -0.05,
+      cameraParams: {
+        fov: 30,
+        near: 0.1,
+        far: 1000,
+        position: new THREE.Vector3(-10, 0, 30),
+        lookAt: new THREE.Vector3(0, 0, 0)
+      },
+      transFunc: (p: Point) => {
+        return {
+          x: p.x / 50,
+          y: p.y / 50,
+          z: p.z / 60,
+          value: p.value
+        };
+      }
+    }
+  }
+];
 const EmbryoGeneration: React.FC = () => {
-  const [cs7Data, setCs7Data] = useState<Point[]>([]);
-  const [cs8Data, setCs8Data] = useState<Point[]>([]);
-  const [cs75Data, setCs75Data] = useState<Point[]>([]);
+  return (
+    <div className="page-container">
+      <div className="page-header">
+        <h1>Embryo Generation</h1>
+        <p className="page-description">
+          Observe cell migration and merging across human CS7/CS8/CS7.5 and mouse 7.5/7.75/8.5 datasets with the same control workflow.
+        </p>
+      </div>
+      <div className="page-content">
+        {ANIMATION_SECTIONS.map((section) => (
+          <EmbryoAnimationSection key={section.id} config={section} />
+        ))}
+        <div className="section">
+          <h2>User Guide</h2>
+          <div style={{ display: "grid", gridTemplateColumns: "repeat(auto-fit, minmax(300px, 1fr))", gap: "2rem", marginTop: "1.5rem" }}>
+            <div>
+              <h3>🎬 Animation controls</h3>
+              <p>Click "Start animation" to watch the CS7.5 cell formation process. Adjust speed and use Reset to start over.</p>
+            </div>
+            <div>
+              <h3>🖱️ Interactions</h3>
+              <p>Drag to rotate, scroll to zoom, and click data points in the 3D view to see details.</p>
+            </div>
+            <div>
+              <h3>🎨 Color encoding</h3>
+              <p>Identical colors indicate the same cell type, making it easier to observe developmental changes.</p>
+            </div>
+            <div>
+              <h3>📊 Developmental process</h3>
+              <p>Observe the process from CS7 and CS8 to CS7.5 to understand spatial distribution changes and cell-type differentiation.</p>
+            </div>
+          </div>
+        </div>
+      </div>
+    </div>
+  );
+};
+
+interface EmbryoAnimationSectionProps {
+  config: AnimationSectionConfig;
+}
+
+const EmbryoAnimationSection: React.FC<EmbryoAnimationSectionProps> = ({ config }) => {
+  const { stages, title, description, layout } = config;
+  const { sourceLeft, sourceRight, target } = stages;
+  const [sourceLeftData, setSourceLeftData] = useState<Point[]>([]);
+  const [sourceRightData, setSourceRightData] = useState<Point[]>([]);
+  const [targetData, setTargetData] = useState<Point[]>([]);
   const [loading, setLoading] = useState(true);
   const [error, setError] = useState("");
   const [animationProgress, setAnimationProgress] = useState(0);
   const [isAnimating, setIsAnimating] = useState(false);
   const [animationSpeed, setAnimationSpeed] = useState(2);
 
-  // 加载数据
   useEffect(() => {
     const loadData = async () => {
       setLoading(true);
       setError("");
       try {
-        const [cs7Res, cs8Res, cs75Res] = await Promise.all([
-          axios.get("http://localhost:5000/api/cell", { params: { stage: "CS7" } }),
-          axios.get("http://localhost:5000/api/cell", { params: { stage: "CS8" } }),
-          axios.get("http://localhost:5000/api/cell", { params: { stage: "CS7.5" } })
+        const [leftRes, rightRes, targetRes] = await Promise.all([
+          axios.get("http://localhost:5000/api/cell", { params: { stage: sourceLeft } }),
+          axios.get("http://localhost:5000/api/cell", { params: { stage: sourceRight } }),
+          axios.get("http://localhost:5000/api/cell", { params: { stage: target } })
         ]);
-        setCs7Data(cs7Res.data.cells);
-        setCs8Data(cs8Res.data.cells);
-        setCs75Data(cs75Res.data.cells);
+        setSourceLeftData(leftRes.data.cells || []);
+        setSourceRightData(rightRes.data.cells || []);
+        setTargetData(targetRes.data.cells || []);
+        setAnimationProgress(0);
+        setIsAnimating(false);
       } catch (err: any) {
         if (err.response && err.response.data?.error) {
           setError(err.response.data.error);
@@ -45,12 +172,12 @@ const EmbryoGeneration: React.FC = () => {
         setLoading(false);
       }
     };
-    loadData();
-  }, []);
 
-  // 动画逻辑
+    loadData();
+  }, [sourceLeft, sourceRight, target]);
+
   useEffect(() => {
-    if (!isAnimating || cs7Data.length === 0 || cs8Data.length === 0 || cs75Data.length === 0) {
+    if (!isAnimating || sourceLeftData.length === 0 || sourceRightData.length === 0 || targetData.length === 0) {
       return;
     }
     const duration = 5000 / animationSpeed;
@@ -67,26 +194,28 @@ const EmbryoGeneration: React.FC = () => {
       }
     };
     animate();
-  }, [isAnimating, cs7Data.length, cs8Data.length, cs75Data.length, animationSpeed]);
+  }, [isAnimating, sourceLeftData.length, sourceRightData.length, targetData.length, animationSpeed]);
 
   const startAnimation = () => {
     setIsAnimating(true);
     setAnimationProgress(0);
   };
+
   const resetAnimation = () => {
     setIsAnimating(false);
     setAnimationProgress(0);
   };
 
+  const datasetLabel = `${sourceLeft} + ${sourceRight} -> ${target}`;
+  const progressPercent = Math.round(animationProgress * 100);
+
   return (
-    <div className="page-container">
-      <div className="page-header">
-        <h1>Embryo Generation</h1>
-        <p className="page-description">
-          Observe cell migration and merging during embryonic development. CS7, CS8, and CS7.5 point clouds are shown in one 3D view, with an animation simulating cells converging from both sides.
-        </p>
+    <section className="section" style={{ marginBottom: "3rem" }}>
+      <div style={{ marginBottom: "1.5rem" }}>
+        <h2 style={{ marginBottom: "0.5rem" }}>{title}</h2>
+        <p className="page-description" style={{ marginBottom: "0.25rem" }}>{description}</p>
+        <p style={{ color: "var(--text-secondary)", margin: 0 }}>Dataset: {datasetLabel}</p>
       </div>
-      <div className="page-content">
       <div className="control-panel" style={{
         display: "flex",
         alignItems: "center",
@@ -141,7 +270,7 @@ const EmbryoGeneration: React.FC = () => {
           <span>{animationSpeed}x</span>
         </label>
         <div style={{ display: "flex", alignItems: "center", gap: "0.5rem" }}>
-            Progress: {Math.round(animationProgress * 100)}%
+          Progress: {progressPercent}%
           <div style={{
             width: "100px",
             height: "8px",
@@ -160,52 +289,56 @@ const EmbryoGeneration: React.FC = () => {
       </div>
       {error && <div className="error-message" style={{ marginBottom: "2rem" }}>{error}</div>}
       <UnifiedEmbryoAnimation
-          cs7Data={cs7Data}
-          cs8Data={cs8Data}
-          cs75Data={cs75Data}
+        sourceLeftData={sourceLeftData}
+        sourceRightData={sourceRightData}
+        targetData={targetData}
         animationProgress={animationProgress}
+        layout={layout}
       />
-        <div className="section">
-          <h2>User Guide</h2>
-          <div style={{ display: "grid", gridTemplateColumns: "repeat(auto-fit, minmax(300px, 1fr))", gap: "2rem", marginTop: "1.5rem" }}>
-            <div>
-              <h3>🎬 Animation controls</h3>
-              <p>Click "Start animation" to watch the CS7.5 cell formation process. Adjust speed and use Reset to start over.</p>
-            </div>
-            <div>
-              <h3>🖱️ Interactions</h3>
-              <p>Drag to rotate, scroll to zoom, and click data points in the 3D view to see details.</p>
-            </div>
-            <div>
-              <h3>🎨 Color encoding</h3>
-              <p>Identical colors indicate the same cell type, making it easier to observe developmental changes.</p>
-            </div>
-            <div>
-              <h3>📊 Developmental process</h3>
-              <p>Observe the process from CS7 and CS8 to CS7.5 to understand spatial distribution changes and cell-type differentiation.</p>
-            </div>
-          </div>
-        </div>
-      </div>
-    </div>
+    </section>
   );
 };
 
-interface UnifiedEmbryoAnimationProps {
-  cs7Data: Point[];
-  cs8Data: Point[];
-  cs75Data: Point[];
-  animationProgress: number;
-}
 
-const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data, cs8Data, cs75Data, animationProgress }) => {
+interface UnifiedEmbryoAnimationProps {
+  sourceLeftData: Point[];
+  sourceRightData: Point[];
+  targetData: Point[];
+  animationProgress: number;
+  layout: LayoutConfig;
+}
+interface TargetAnimationState {
+  positionsAttr: THREE.BufferAttribute;
+  alphaAttr: THREE.BufferAttribute;
+  fromPositions: Float32Array;
+  toPositions: Float32Array;
+  delays: Float32Array;
+  moveDuration: number;
+  fadeInDuration: number;
+}
+const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ sourceLeftData, sourceRightData, targetData, animationProgress, layout }) => {
   const containerRef = useRef<HTMLDivElement | null>(null);
   const rendererRef = useRef<THREE.WebGLRenderer | null>(null);
   const sceneRef = useRef<THREE.Scene | null>(null);
   const controlsRef = useRef<any>(null);
   const animationIdRef = useRef<number | null>(null);
+  const animationStateRef = useRef<TargetAnimationState | null>(null);
+
+  const { leftOffsetX, rightOffsetX, targetOffsetX = 0, cameraParams, transFunc = null } = layout;
+
+  if (transFunc) {
+    for (let i = 0; i < sourceLeftData.length; i++) {
+      if (i < 5) console.log(`Source Left Point ${i}: original (${sourceLeftData[i].x.toFixed(2)}, ${sourceLeftData[i].y.toFixed(2)}, ${sourceLeftData[i].z.toFixed(2)})`);
+      sourceLeftData[i] = transFunc(sourceLeftData[i]);
+    }
+    for (let i = 0; i < sourceRightData.length; i++) {
+      sourceRightData[i] = transFunc(sourceRightData[i]);
+    }
+    for (let i = 0; i < targetData.length; i++) {
+      targetData[i] = transFunc(targetData[i]);
+    }
+  }
 
-  // 颜色映射
   const getColorMap = (allData: Point[]) => {
     const cellTypes = Array.from(new Set(allData.map(p => p.value as string))).sort();
     const colors = [
@@ -221,9 +354,37 @@ const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data
     return colorMap;
   };
 
+  const applyAnimationProgress = useCallback((progress: number) => {
+    const animationState = animationStateRef.current;
+    if (!animationState) return;
+    const { positionsAttr, alphaAttr, fromPositions, toPositions, delays, moveDuration, fadeInDuration } = animationState;
+    const positionsArray = positionsAttr.array as Float32Array;
+    const alphaArray = alphaAttr.array as Float32Array;
+    const total = delays.length;
+    for (let i = 0; i < total; i++) {
+      const delay = delays[i];
+      let pointProgress = (progress - delay) / moveDuration;
+      pointProgress = Math.max(0, Math.min(1, pointProgress));
+      const easeProgress = pointProgress < 0.5
+        ? 2 * pointProgress * pointProgress
+        : 1 - Math.pow(-2 * pointProgress + 2, 2) / 2;
+      const baseIndex = i * 3;
+      positionsArray[baseIndex] = fromPositions[baseIndex] + (toPositions[baseIndex] - fromPositions[baseIndex]) * easeProgress;
+      positionsArray[baseIndex + 1] = fromPositions[baseIndex + 1] + (toPositions[baseIndex + 1] - fromPositions[baseIndex + 1]) * easeProgress;
+      positionsArray[baseIndex + 2] = fromPositions[baseIndex + 2] + (toPositions[baseIndex + 2] - fromPositions[baseIndex + 2]) * easeProgress;
+
+      const fadeProgress = Math.min(pointProgress / fadeInDuration, 1);
+      alphaArray[i] = fadeProgress;
+    }
+    positionsAttr.needsUpdate = true;
+    alphaAttr.needsUpdate = true;
+  }, []);
+
   useEffect(() => {
     if (!containerRef.current) return;
-    // 清理
+
+    animationStateRef.current = null;
+
     if (animationIdRef.current !== null) {
       cancelAnimationFrame(animationIdRef.current);
       animationIdRef.current = null;
@@ -232,16 +393,22 @@ const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data
       rendererRef.current.dispose();
       rendererRef.current = null;
     }
+    if (controlsRef.current) {
+      controlsRef.current.dispose();
+      controlsRef.current = null;
+    }
+    if (containerRef.current) {
       while (containerRef.current.firstChild) {
         containerRef.current.removeChild(containerRef.current.firstChild);
       }
-    // 初始化
+    }
+
     const width = containerRef.current.clientWidth;
     const height = containerRef.current.clientHeight;
     const scene = new THREE.Scene();
     sceneRef.current = scene;
-    const camera = new THREE.PerspectiveCamera(30, width / height, 0.1, 1000);
-    camera.position.set(0, 0, 30);
+    const camera = new THREE.PerspectiveCamera(cameraParams.fov, width / height, cameraParams.near, cameraParams.far);
+    camera.position.set(cameraParams.position.x, cameraParams.position.y, cameraParams.position.z);
     camera.lookAt(0, 0, 0);
     const renderer = new THREE.WebGLRenderer({ antialias: true });
     renderer.setSize(width, height);
@@ -250,42 +417,28 @@ const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data
     const controls = new OrbitControls(camera, renderer.domElement);
     controls.enableDamping = true;
     controlsRef.current = controls;
-    // 不添加坐标轴
 
-    // 颜色映射
-    const allData = [...cs7Data, ...cs8Data, ...cs75Data];
+    const disposableMaterials: THREE.Material[] = [];
+    const disposableGeometries: THREE.BufferGeometry[] = [];
+    const disposableTextures: THREE.Texture[] = [];
+    const pointTexture = createTexture();
+    disposableTextures.push(pointTexture);
+
+    const allData = [...sourceLeftData, ...sourceRightData, ...targetData];
     const colorMap = getColorMap(allData);
+    const allPositions: number[] = [];
+    const recordPosition = (x: number, y: number, z: number) => {
+      allPositions.push(x, y, z);
+    };
 
-    // 计算所有点的包围盒，自动居中和缩放
-    let allPositions: number[] = [];
-    cs7Data.forEach(p => { allPositions.push(p.x - 0.5, p.y, p.z); });
-    cs8Data.forEach(p => { allPositions.push(p.x + 0.5,p.y, p.z); });
-    cs75Data.forEach((p, i) => {
-      const fromX = i % 2 === 0 ? p.x - 0.5 : p.x + 0.5;
-      allPositions.push(fromX, p.y, p.z);
-      allPositions.push(p.x, p.y, p.z);
-    });
-    if (allPositions.length > 0) {
-      const posArr = new Float32Array(allPositions);
-      const box = new THREE.Box3().setFromArray(posArr);
-      const center = new THREE.Vector3();
-      box.getCenter(center);
-      const size = new THREE.Vector3();
-      box.getSize(size);
-      // 让最大边长适配canvas
-      const maxDim = Math.max(size.x, size.y, size.z);
-      const fitScale = 32 / maxDim; // 32为经验缩放系数
-      scene.position.set(-center.x, -center.y, -center.z);
-      scene.scale.set(fitScale, fitScale, fitScale);
-    }
-
-    // CS7点云（左，静态）
-    if (cs7Data.length > 0) {
+    if (sourceLeftData.length > 0) {
       const geometry = new THREE.BufferGeometry();
       const positions: number[] = [];
       const colors: number[] = [];
-      cs7Data.forEach((p) => {
-        positions.push(p.x - 0.5, p.y, p.z);
+      sourceLeftData.forEach((p) => {
+        const shiftedX = p.x + leftOffsetX;
+        positions.push(shiftedX, p.y, p.z);
+        recordPosition(shiftedX, p.y, p.z);
         const c = colorMap.get(p.value as string) || new THREE.Color('#CCCCCC');
         colors.push(c.r, c.g, c.b);
       });
@@ -299,35 +452,22 @@ const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data
         alphaTest: 0.5,
         depthWrite: false,
         blending: THREE.NormalBlending,
-        map: (() => {
-          const canvas = document.createElement('canvas');
-          canvas.width = 64;
-          canvas.height = 64;
-          const ctx = canvas.getContext('2d')!;
-          ctx.clearRect(0, 0, 64, 64);
-          // 绘制带有alpha渐变的圆形
-          const gradient = ctx.createRadialGradient(32, 32, 0, 32, 32, 30);
-          gradient.addColorStop(0, 'rgba(255,255,255,1)');
-          gradient.addColorStop(0.98, 'rgba(255,255,255,1)');
-          gradient.addColorStop(1, 'rgba(255,255,255,0)');
-          ctx.beginPath();
-          ctx.arc(32, 32, 30, 0, 2 * Math.PI);
-          ctx.closePath();
-          ctx.fillStyle = gradient;
-          ctx.fill();
-          return new THREE.CanvasTexture(canvas);
-        })()
+        map: pointTexture
       });
       const points = new THREE.Points(geometry, material);
       scene.add(points);
+      disposableGeometries.push(geometry);
+      disposableMaterials.push(material);
     }
-    // CS8点云（右，静态）
-    if (cs8Data.length > 0) {
+
+    if (sourceRightData.length > 0) {
       const geometry = new THREE.BufferGeometry();
       const positions: number[] = [];
       const colors: number[] = [];
-      cs8Data.forEach((p) => {
-        positions.push(p.x + 0.5, p.y, p.z);
+      sourceRightData.forEach((p) => {
+        const shiftedX = p.x + rightOffsetX;
+        positions.push(shiftedX, p.y, p.z);
+        recordPosition(shiftedX, p.y, p.z);
         const c = colorMap.get(p.value as string) || new THREE.Color('#CCCCCC');
         colors.push(c.r, c.g, c.b);
       });
@@ -341,122 +481,118 @@ const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data
         alphaTest: 0.5,
         depthWrite: false,
         blending: THREE.NormalBlending,
-        map: (() => {
-          const canvas = document.createElement('canvas');
-          canvas.width = 64;
-          canvas.height = 64;
-          const ctx = canvas.getContext('2d')!;
-          ctx.clearRect(0, 0, 64, 64);
-          // 绘制带有alpha渐变的圆形
-          const gradient = ctx.createRadialGradient(32, 32, 0, 32, 32, 30);
-          gradient.addColorStop(0, 'rgba(255,255,255,1)');
-          gradient.addColorStop(0.98, 'rgba(255,255,255,1)');
-          gradient.addColorStop(1, 'rgba(255,255,255,0)');
-          ctx.beginPath();
-          ctx.arc(32, 32, 30, 0, 2 * Math.PI);
-          ctx.closePath();
-          ctx.fillStyle = gradient;
-          ctx.fill();
-          return new THREE.CanvasTexture(canvas);
-        })()
+        map: pointTexture
       });
       const points = new THREE.Points(geometry, material);
       scene.add(points);
+      disposableGeometries.push(geometry);
+      disposableMaterials.push(material);
     }
-    // CS7.5点云（动画）
-    if (cs75Data.length > 0) {
+
+    const pickFallbackPoint = (preferred: Point[], alternative: Point[], index: number, defaultPoint: Point): Point => {
+      if (preferred.length > 0) {
+        return preferred[index % preferred.length];
+      }
+      if (alternative.length > 0) {
+        return alternative[index % alternative.length];
+      }
+      return defaultPoint;
+    };
+
+    if (targetData.length > 0) {
       const geometry = new THREE.BufferGeometry();
-      const positions: number[] = [];
-      const colors: number[] = [];
-      const alphas: number[] = [];
-      const n = cs75Data.length;
-      const moveDuration = 0.4; // 每个点的动画持续时间（占总进度的比例）
-      const delayPerPoint = 0.6 / n; // 剩余0.6进度用于错峰
+      const n = targetData.length;
+      const positionsArray = new Float32Array(n * 3);
+      const colorsArray = new Float32Array(n * 3);
+      const alphasArray = new Float32Array(n);
+      const fromPositions = new Float32Array(n * 3);
+      const toPositions = new Float32Array(n * 3);
+      const delays = new Float32Array(n);
+      const moveDuration = 0.4;
+      const delayPerPoint = n > 0 ? 0.6 / n : 0;
+      const fadeInDuration = 0.3;
 
-      // 为CS7.5的点分配起始位置（从CS7和CS8的实际数据中获取）
-      // 基于细胞类型或颜色来分配起始位置，确保相同颜色的点从两侧出现
-      // Left/right source point placeholders removed (unused)
-
-      // 按细胞类型分组CS7和CS8数据
-      const cs7ByType = new Map<string, Point[]>();
-      const cs8ByType = new Map<string, Point[]>();
-
-      cs7Data.forEach(point => {
+      const sourceLeftByType = new Map<string, Point[]>();
+      sourceLeftData.forEach(point => {
         const type = point.value as string;
-        if (!cs7ByType.has(type)) cs7ByType.set(type, []);
-        cs7ByType.get(type)!.push(point);
+        if (!sourceLeftByType.has(type)) sourceLeftByType.set(type, []);
+        sourceLeftByType.get(type)!.push(point);
       });
 
-      cs8Data.forEach(point => {
+      const sourceRightByType = new Map<string, Point[]>();
+      sourceRightData.forEach(point => {
         const type = point.value as string;
-        if (!cs8ByType.has(type)) cs8ByType.set(type, []);
-        cs8ByType.get(type)!.push(point);
+        if (!sourceRightByType.has(type)) sourceRightByType.set(type, []);
+        sourceRightByType.get(type)!.push(point);
       });
 
       for (let i = 0; i < n; i++) {
-        const to = cs75Data[i];
+        const to = targetData[i];
+        if (i < 5) console.log(`Target Point ${i}: to (${to.x.toFixed(2)}, ${to.y.toFixed(2)}, ${to.z.toFixed(2)})`);
         const cellType = to.value as string;
-        let fromX, fromY, fromZ;
-
-        // 基于细胞类型和索引的奇偶性来决定从哪一侧开始
         const shouldStartFromLeft = i % 2 === 0;
-
+        let sourcePoint: Point;
         if (shouldStartFromLeft) {
-          // 从左侧CS7数据开始
-          const cs7PointsOfType = cs7ByType.get(cellType) || [];
-          const sourceIndex = Math.floor(i / 2) % cs7PointsOfType.length;
-          const sourcePoint = cs7PointsOfType.length > 0
-            ? cs7PointsOfType[sourceIndex]
-            : cs7Data[i % cs7Data.length];
-          fromX = sourcePoint.x - 0.5;
-          fromY = sourcePoint.y;
-          fromZ = sourcePoint.z;
+          const pointsOfType = sourceLeftByType.get(cellType) || [];
+          if (pointsOfType.length > 0) {
+            const sourceIndex = Math.floor(i / 2) % pointsOfType.length;
+            sourcePoint = pointsOfType[sourceIndex];
           } else {
-          // 从右侧CS8数据开始
-          const cs8PointsOfType = cs8ByType.get(cellType) || [];
-          const sourceIndex = Math.floor(i / 2) % cs8PointsOfType.length;
-          const sourcePoint = cs8PointsOfType.length > 0
-            ? cs8PointsOfType[sourceIndex]
-            : cs8Data[i % cs8Data.length];
-            fromX = sourcePoint.x + 0.5;
-          fromY = sourcePoint.y;
-          fromZ = sourcePoint.z;
+            sourcePoint = pickFallbackPoint(sourceLeftData, sourceRightData, i, to);
+          }
+        } else {
+          const pointsOfType = sourceRightByType.get(cellType) || [];
+          if (pointsOfType.length > 0) {
+            const sourceIndex = Math.floor(i / 2) % pointsOfType.length;
+            sourcePoint = pointsOfType[sourceIndex];
+          } else {
+            sourcePoint = pickFallbackPoint(sourceRightData, sourceLeftData, i, to);
+          }
         }
 
-        // 添加一些随机延迟，使动画更自然
+        const offsetX = shouldStartFromLeft ? leftOffsetX : rightOffsetX;
+        const fromBaseIndex = i * 3;
+        const fromX = sourcePoint.x + offsetX;
+        const fromY = sourcePoint.y;
+        const fromZ = sourcePoint.z;
+        const toBaseX = to.x + targetOffsetX;
+        const toBaseY = to.y;
+        const toBaseZ = to.z;
+
+        if (i < 5) {
+          console.log(`Point ${i}: from (${fromX.toFixed(2)}, ${fromY.toFixed(2)}, ${fromZ.toFixed(2)}) to (${toBaseX.toFixed(2)}, ${toBaseY.toFixed(2)}, ${toBaseZ.toFixed(2)})`);
+        }
+
+        fromPositions[fromBaseIndex] = fromX;
+        fromPositions[fromBaseIndex + 1] = fromY;
+        fromPositions[fromBaseIndex + 2] = fromZ;
+        toPositions[fromBaseIndex] = toBaseX;
+        toPositions[fromBaseIndex + 1] = toBaseY;
+        toPositions[fromBaseIndex + 2] = toBaseZ;
+
+        positionsArray[fromBaseIndex] = fromX;
+        positionsArray[fromBaseIndex + 1] = fromY;
+        positionsArray[fromBaseIndex + 2] = fromZ;
+
+        const color = colorMap.get(cellType) || new THREE.Color('#CCCCCC');
+        colorsArray[fromBaseIndex] = color.r;
+        colorsArray[fromBaseIndex + 1] = color.g;
+        colorsArray[fromBaseIndex + 2] = color.b;
+
+        alphasArray[i] = 0;
+
+        recordPosition(fromX, fromY, fromZ);
+        recordPosition(toBaseX, toBaseY, toBaseZ);
+
         const baseDelay = i * delayPerPoint;
-        const randomDelay = (Math.random() - 0.5) * 0.1; // 添加±0.05的随机延迟
-        const delay = baseDelay + randomDelay;
-
-        let pointProgress = (animationProgress - delay) / moveDuration;
-        pointProgress = Math.max(0, Math.min(1, pointProgress));
-
-        // 使用缓动函数使动画更平滑
-        const easeProgress = pointProgress < 0.5
-          ? 2 * pointProgress * pointProgress
-          : 1 - Math.pow(-2 * pointProgress + 2, 2) / 2;
-
-        const x = fromX + (to.x - fromX) * easeProgress;
-        const y = fromY + (to.y - fromY) * easeProgress;
-        const z = fromZ + (to.z - fromZ) * easeProgress;
-
-        // 计算透明度：从透明(0)到不透明(1)
-        // 透明度在动画的前30%时间内从0过渡到1
-        const fadeInDuration = 0.3;
-        const fadeProgress = Math.min(pointProgress / fadeInDuration, 1);
-        const alpha = fadeProgress;
-
-        positions.push(x, y, z);
-        const c = colorMap.get(to.value as string) || new THREE.Color('#CCCCCC');
-        colors.push(c.r, c.g, c.b);
-        alphas.push(alpha);
+        const randomDelay = (Math.random() - 0.5) * 0.1;
+        delays[i] = baseDelay + randomDelay;
       }
 
-      geometry.setAttribute("position", new THREE.Float32BufferAttribute(positions, 3));
-      geometry.setAttribute("color", new THREE.Float32BufferAttribute(colors, 3));
-      geometry.setAttribute("alpha", new THREE.Float32BufferAttribute(alphas, 1));
+      geometry.setAttribute("position", new THREE.Float32BufferAttribute(positionsArray, 3));
+      geometry.setAttribute("color", new THREE.Float32BufferAttribute(colorsArray, 3));
+      geometry.setAttribute("alpha", new THREE.Float32BufferAttribute(alphasArray, 1));
 
-      // 创建自定义着色器材质来处理透明度
       const vertexShader = `
         attribute float alpha;
         attribute vec3 color;
@@ -475,59 +611,94 @@ const UnifiedEmbryoAnimation: React.FC<UnifiedEmbryoAnimationProps> = ({ cs7Data
         varying float vAlpha;
         varying vec3 vColor;
         void main() {
-          // 使用纹理贴图
           vec4 texColor = texture2D(pointTexture, gl_PointCoord);
-
-          // 计算当前片段在点内的相对位置
           vec2 center = gl_PointCoord - vec2(0.5);
           float dist = length(center);
-
-          // 创建圆形遮罩，距离中心0.5半径内的片段可见
           if (dist > 0.5) {
-            discard; // 丢弃圆形外的片段
+            discard;
           }
-
-          // 将纹理颜色与顶点颜色混合
           gl_FragColor = vec4(vColor * texColor.rgb, vAlpha * texColor.a);
         }
       `;
 
-      const texture = createTexture(); // 创建纹理贴图（与PointsMaterial相同）
-
       const material = new THREE.ShaderMaterial({
-        vertexShader: vertexShader,
-        fragmentShader: fragmentShader,
+        vertexShader,
+        fragmentShader,
         transparent: true,
         depthWrite: false,
-
         blending: THREE.NormalBlending,
         uniforms: {
-          pointTexture: { value: texture }
+          pointTexture: { value: pointTexture }
         }
       });
       const points = new THREE.Points(geometry, material);
       scene.add(points);
+      disposableGeometries.push(geometry);
+      disposableMaterials.push(material);
+
+      animationStateRef.current = {
+        positionsAttr: geometry.getAttribute("position") as THREE.BufferAttribute,
+        alphaAttr: geometry.getAttribute("alpha") as THREE.BufferAttribute,
+        fromPositions,
+        toPositions,
+        delays,
+        moveDuration,
+        fadeInDuration
+      };
+    } else {
+      animationStateRef.current = null;
     }
-    // 渲染循环
+
+    if (allPositions.length > 0) {
+      const posArr = new Float32Array(allPositions);
+      const box = new THREE.Box3().setFromArray(posArr);
+      const center = new THREE.Vector3();
+      box.getCenter(center);
+      const size = new THREE.Vector3();
+      box.getSize(size);
+      const maxDim = Math.max(size.x, size.y, size.z);
+      const fitScale = maxDim === 0 ? 1 : 32 / maxDim;
+      scene.position.set(-center.x, -center.y, -center.z);
+      scene.scale.set(fitScale, fitScale, fitScale);
+    }
+
     const animate = () => {
       animationIdRef.current = requestAnimationFrame(animate);
       controls.update();
       renderer.render(scene, camera);
     };
     animate();
-    // 清理
+
+    applyAnimationProgress(animationProgress);
+
     return () => {
       if (animationIdRef.current !== null) {
         cancelAnimationFrame(animationIdRef.current);
+        animationIdRef.current = null;
       }
       if (controlsRef.current) {
         controlsRef.current.dispose();
+        controlsRef.current = null;
       }
       if (rendererRef.current) {
         rendererRef.current.dispose();
+        rendererRef.current = null;
       }
+      disposableMaterials.forEach((material) => material.dispose());
+      disposableGeometries.forEach((geometry) => geometry.dispose());
+      disposableTextures.forEach((texture) => texture.dispose());
+      if (containerRef.current) {
+        while (containerRef.current.firstChild) {
+          containerRef.current.removeChild(containerRef.current.firstChild);
+        }
+      }
+      animationStateRef.current = null;
     };
-  }, [cs7Data, cs8Data, cs75Data, animationProgress]);
+  }, [sourceLeftData, sourceRightData, targetData, leftOffsetX, rightOffsetX, targetOffsetX, applyAnimationProgress]);
+
+  useEffect(() => {
+    applyAnimationProgress(animationProgress);
+  }, [animationProgress, applyAnimationProgress]);
 
   return <div ref={containerRef} className="point-cloud-container" style={{ width: "100%", height: "700px", minHeight: 600 }} />;
 };
@@ -551,5 +722,4 @@ const createTexture = () => {
   ctx.fill();
   return new THREE.CanvasTexture(canvas);
 };
-
 export default EmbryoGeneration;