From bfb8e9a274be102bce8de28450f242596c82715d Mon Sep 17 00:00:00 2001 From: Flash Date: Sat, 26 Jul 2025 11:50:35 +0800 Subject: [PATCH] =?UTF-8?q?=E6=B7=BB=E5=8A=A0=20=E9=A1=B9=E7=9B=AE?= =?UTF-8?q?=E5=8F=82=E8=80=83=E7=BD=91=E7=AB=99?= MIME-Version: 1.0 Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: 8bit --- ...A1%B9%E7%9B%AE%E5%8F%82%E8%80%83%E7%BD%91%E7%AB%99.md | 9 +++++++++ 1 file changed, 9 insertions(+) create mode 100644 %E9%A1%B9%E7%9B%AE%E5%8F%82%E8%80%83%E7%BD%91%E7%AB%99.md diff --git a/%E9%A1%B9%E7%9B%AE%E5%8F%82%E8%80%83%E7%BD%91%E7%AB%99.md b/%E9%A1%B9%E7%9B%AE%E5%8F%82%E8%80%83%E7%BD%91%E7%AB%99.md new file mode 100644 index 0000000..6d9f4bb --- /dev/null +++ b/%E9%A1%B9%E7%9B%AE%E5%8F%82%E8%80%83%E7%BD%91%E7%AB%99.md @@ -0,0 +1,9 @@ +1. [**人的CS12-CS23的空间转录组数据分析网站**](https://db.cngb.org/stomics/hesta/) + +> The spatial and temporal atlas of gene expression in human embryo at early gestation is critical in understanding embryo development, organogenesis and disease origins. Here, we obtained the spatial-temporal transcriptome from the 77 sagittal sections of 13 human embryos at 12-23 Carnegie stage (CS) by Stereo-seq, established the development trajectory/regulatory profiling of 50 organs, and identified the top organ-specific regulons with the highest score as the potential organ-identity regulators. The atlas refines the key organs/cell types that are vulnerable to virus infection and genetic disorders. We found dynamic changes of imprinting gene expression in specific organs at different stages. Our work, for the first time, revealed the time-lapse and spatial transcriptome dynamics of human embryogenesis after gastrulation. + +2. [**小鼠的E9.5-E16.5的空间转录组数据分析平台**](https://db.cngb.org/stomics/mosta/) + +> MOSTA database has a total of 53 sagittal sections from C57BL/6 mouse embryos at E9.5 (~7.1 mm2), E10.5 (~11.5 mm2), E11.5 (~18.8 mm2), E12.5 (~32.1 mm2), E13.5 (~48.4 mm2), E14.5 (~64.1 mm2), E15.5 (~70.8 mm2) and E16.5 (~76.1 mm2) using Stereo-seq. For E9.5-E15.5 stages, four to six sections were included from different replicates. As for E16.5, 17 sagittal sections were profiled from two biological replicates, with 13 sections from one single embryo, allowing coverage of all major organs/tissues. In the MOSTA, we provide the spatial map showing the gene expression, gene co-expression modules and regulons in each embryo sagittal sections. Our panoramic atlas will allow in-depth investigation of longstanding questions concerning mammalian development. + +3. 人CS8时期的空间转录组数据分析平台 \ No newline at end of file